Experimental study demonstrates that Acod1 suppresses osteoclast differentiation in arthritis models, suggesting metabolic targets for joint preservation.
Metabolic changes are crucially involved in osteoclast development and may contribute to bone degradation in rheumatoid arthritis (RA). The enzyme aconitate decarboxylase 1 (Acod1) is known to link the cellular function of monocyte-derived macrophages to their metabolic status. As osteoclasts derive from the monocyte lineage, we hypothesised a role for Acod1 and its metabolite itaconate in osteoclast differentiation and arthritis-associated bone loss.
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Kachler et al. (2024) studied this question.
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