Extensive mobile health technology assessment detects subtle motor impairment in mild and asymptomatic Pompe disease

Abstract The aim of the study was to evaluate the ability of mobile health technology (MHT) to detect and quantify mobility alterations in late-onset Pompe Disease (PD). The study enrolled eight subjects with PD, including three young mildly affected/asymptomatic subjects, who underwent an extensive MHT mobility assessment and were contrasted to matched controls. MHT assessment enabled the detection of subtle mobility alterations, indicating a lower speed in walking, postural transition and turning lower performances in PD subjects compared to controls. Interestingly, in the three mildly affected/asymptomatic cases, clinical scales and timed tests scored within the normal ranges, whereas gait digital parameters showed detectable subtle alterations compared to controls.