Abstract Objective: Peripheral nerve injuries are commonly encountered in clinical practice. Peripheral nerve injuries most commonly resultin serious problems affecting quality of life. The present study is designed to research the possible neuroprotective effects of Ankaferd blood stopper (ABS), Platelet-rich plasma (PRP) and Momordica charantia (MC) on regeneration using unbiased stereological techniques. Material-Method: 30 female 8-10 weeks-Sprague Dawley rats were randomly divided into five equal groups; control (CG), the group exposed to sciatic nerve resection (Gap) (CGG), additionally following the surgical process ABS, MC and PRP were injected into collagen tube (ABSG, MCG, PRPG). Nucleator and fractionator methods were used to estimate the number of myelinated and unmyelinated axons, axon area, and myelin sheath thickness. Also, an electron microscopic evaluation was performed. Results: Regarding the number of myelinated axons, significant increases were found in the ABSG, MCG and PRPG compared to CG (p<0.05). Conclusion: The protective effects of ABS, PRP, and MC on peripheral nerve regeneration in experimental models in rats were shown using electrophysiological and stereological assessment parameters.
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Önger et al. (2024) studied this question.
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