Abstract In this study, equine intestinal enteroids (EIEs) were generated from the duodenum, jejunum, and ileum and inoculated with equine coronavirus (ECoV) to investigate their suitability as in vitro models with which to study ECoV infection. Immunohistochemistry revealed that the EIEs were composed of various cell types expressed in vivo in the intestinal epithelium. qRT-PCR and electron microscopy showed that ECoV had infected and replicated in the EIEs. These results suggest that EIEs can be novel in vitro tools for studying the interaction between equine intestinal epithelium and ECoV. (88 words)
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Kambayashi et al. (2024) studied this question.
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