Investigation of the Effect of Peptide p5 Targeting CDK5-p25 Hyperactivity on Munc18–1 (P67) Regulating Neuronal Exocytosis Using Molecular Simulations

Munc18-1 is an SM (sec1/munc-like) family protein involved in vesicle fusion and neuronal exocytosis. Munc18-1 is known to regulate the exocytosis process by binding with closed- and open-state conformations of Syntaxin1, a protein belonging to the SNARE family established to be central to the exocytosis process. Our previous work studied peptide p5 as a promising drug candidate for CDK5-p25 complex, an Alzheimer's disease (AD) pathological target. Experimental