"Gemcitabine Based Chemotherpy and Maintenance with Thalidomide in Untreated Patients with Mycosis Fungoide"

Mycosis fungoides is the most common of cutaneous T-cell lymphomas, until now the best treatment has not been defined, probably because actual treatments are palliative, and when the tumor is refractory/ relapse , response and outcomes are poor 'Thus we developed an regimen with gemcitabine- based combined chemotherapy, two drugs with proven efficacy in T-cell lymphomas , and dexamethasone, if the patient achieved complete response , they were allocated in an proportion 1:1, to received thalidomide in 21 of 28 days cycles by 3 years One hundred and twenty-six patients recruit ,122 (88%) achieved complete and were allocate to received thalidomide or control group.