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July 1, 2024CNS Neuroscience & TherapeuticsOpen Access

Activation of GPER1 by G1 prevents PTSD‐like behaviors in mice: Illustrating the mechanisms from BDNF/TrkB to mitochondria and synaptic connection

Lixia Chen Yang Zhang Zisheng Wang Zhengrong Zhang Jingji Wang Guoqi Zhu Shaojie Yang

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Abstract

G1 is a specific agonist of G protein-coupled estrogen receptor 1 (GPER1), which binds and activates GPER1 to exert various neurological functions. However, the preventive effect of G1 on post-traumatic stress disorder (PTSD) and its mechanisms are unclear.

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Chen et al. (2024) studied this question.

synapsesocial.com/papers/68e61deab6db6435875afbe5 https://doi.org/10.1111/cns.14855

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