Supplementary Figure S4 from Monitoring Hepatocellular Carcinoma Using Tumor Content in Circulating Cell-Free DNA

Supplementary Figure S4. Temporal change of tumor content in pre-HCC samples. (A) Temporal change of tumor content using blood samples collected 0 to 7 years before clinical diagnosis of HCC. The horizontal dashed line in red indicates cutoff value at 0.03. The solid regression line in black was obtained using locally estimated scatterplot smoothing method. (B) A representative example of genome-wide copy number profile change in an HCC patient with seven samples collected prior to diagnosis. The colors green, blue, dark red, and red correspond to copy number deletion, neutral, gain, and amplification, respectively