Comparative study between effect of topical sucralfate cream and glyceryl trinitrate cream on post haemorrhoidectomy pain and wound healing

Background: Haemorrhoidectomy is the treatment of choice for third- and fourth-degree haemorrhoids.Haemorrhoidectomy is avoided by many patients because it is linked to severe pain after surgery.Topical sucralfate cream hastens the healing of wounds and reduces discomfort following hemorrhoidal surgery. After ahaemorrhoidectomy, topical use of glyceryl trinitrate (GTN) can reduce spasm and postoperative pain; also, increase Anodermal blood flow, and accelerate the healing of the wound.Patients and Methods: This prospective randomized control single-blinded study was conducted over a one-yearduration. In General Surgery Department, Mansoura Faculty of Medicine with the inclusion of 60 patients with third- andfourth-degree piles who underwent conventional Milligan–Morgan haemorridectomy.Three groups of 60 patients were randomly assigned to participate in the current study: group A (the control group):included 20 patients who received a placebo (petrolatum cream). group B (the sucralfate group), group C (GTN creamgroup).The visual analogue scale (VAS 0–10) was used to assess postoperative pain on days 1, 7, and 14 following surgery andwound healing was assessed after 28 days.Results: There was no significant difference between the three study groups as regards demographic data, symptoms, andthe VAS score on the first postoperative day.On the seventh and 14th day postoperative, respectively, the VAS score was statistically significantly lower in the GTNgroup followed by the Sucralfate group and finally the control group (P<0.001). The duration for complete wound healingand the duration to return to daily activities were statistically significantly shorter in the sucralfate group followed by theGTN group.