OP-144 Long-term neurodevelopmental effects of exclusively high cord lactate levels in term new-born

Aim This study was conducted to evaluate the effect of cord arterial blood gas analysis (ABGA) lactate level on long-term neurodevelopment of new-borns without any clinical signs of perinatal asphyxia Material and Method Cases with a 5-minute Apgar score <7, sign of fetal distress in their antenatal follow-up were excluded. The cases (n=1438) were divided into two groups those with high cord lactate level (above 5 mmol/L, n=92) and those with low lactate level (below 2 mmol/L, n=255). An Ages & Stages Questionnaire, Third Edition (ASQ-3) developmental screening questionnaire was sent to all parents. Patients with a chronological age between 24–42 months and for whom the questionnaire was fulfilled by the parents (low lactate group, n=29, and high lactate group, n=45) were evaluated. Results No difference was observed between two groups in terms of demographic characteristics such as age (p=0.1669), male gender (p=0.906), mother's working situation (p=0.948), mother's education level (p =0.828), father's education level (p=0.507), and family's total income (p=0.642). Mean ACQ-3 developmental screening test scores were significantly lower in the high lactate group compared to the low lactate group concerning; fine motor (40 vs. 60, p=0.001), problem-solving (50 vs. 60, p=0.002) and personal social development (45 vs. 60, p=0.003) (table 1). No difference was observed in terms of communication and gross motor total scores. Conclusions We observed that cases with a normal 5-minute Apgar score, no suspected perinatal asphyxia, and a cord lactate value of ≥5 fell behind their peers when evaluated with the ACQ-3 developmental screening questionnaire.