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July 1, 2024Asian Pacific Journal of Cancer PreventionOpen Access

Unraveling Copy Number Alterations in Pediatric B-Cell Acute Lymphoblastic Leukemia: Correlation with Induction Phase Remission Using MLPA

Mururul Aisyi Murti Andriastuti Agus Susanto Kosasih Ahmad Rusdan Handoyo Utomo Fahreza Saputra Teny Tjitra Sari Hikari Ambara Sjakti Fifi Dwijayanti Kuntjoro Harimurti Djajadiman Gatot

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Abstract

Acute Lymphoblastic Leukemia (ALL) is the most common malignancy occurring in children. Copy number alterations (CNA) like PAX5, CDKN2A/2B, PAR1 Region, ETV6, IKZF1, BTG1, and RB1 gene deletion are important genetic events that define and prognosticate B-cell ALL. Thus, this study aimed to evaluate associations of CNA with induction phase remission status in childhood B-cell ALL.

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Cite This Study

Aisyi et al. (2024) studied this question.

synapsesocial.com/papers/68e62391b6db6435875b6367 https://doi.org/10.31557/apjcp.2024.25.7.2421

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Clinical significance of recurrent copy number aberrations in B‐lineage acute lymphoblastic leukaemia without recurrent fusion genes across age cohortsPrognostic Study · 2017 · 25 citations
2Genomic characterization and prognostic significance of copy number alterations in Tunisian patients with acute lymphoblastic leukemiaOriginal Research · 2026
3Combination of p-STAT5, CRLF2 and copy number alterations as a potential indicator of a high-risk subgroup of acute lymphoblastic leukemiaOriginal Research · 2026
4Digital Multiplex Ligation-Dependent Probe Amplification for Detection of Key Copy Number Alterations in T- and B-Cell Lymphoblastic LeukemiaOriginal Research · 2017 · 42 citations
5Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic LeukemiaPrognostic Study · 2016 · 333 citations

More related papers

PAX5 Alterations in a Consecutive Childhood B-Cell Acute Lymphoblastic Leukemia Cohort Treated Using the ALL IC-BFM 2009 Protocol2024
Pediatric B-Cell Acute Lymphoblastic Leukemia: Comprehensive Genomic Characterization Including SNP-Array and Analysis of Relapse Risk2026
Molecular genetic characteristics and clinical significance of childhood acute lymphoblastic leukemia2025

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