Predictors Of Marketing Authorization Status Of Dipyrone Within A Country

Introduction. Although there are numerous data about increased risk of bone marrow toxicity with dipyrone when compared to other nonsteroid anti-infl ammatory drugs, it continues to be marketed in many countries. The aim of this study was to identify currently unknown putative predictors of dipyrone having marketing authorization in a country. Methods. The study was designed as secondary research of a cross-sectional type. The data were collected from web pages of relevant international and national entities. The main outcome variable of the study was dipyrone marketing authorization status within a country. The data were analyzed by both uni- and multi-variate statistics, including logistic regression. Results. The following factors showed signifi cant infl uence on marketing authorization status of dipyrone: Current Health Expenditure per capita (p = 0.02), Gross Domestic Product per capita (p = 0.02), Incarceration Rate (per 100.000 population) (p = 0.04), and overall Global Innovati-on Index (p = 0.04). However, after adjustment, the multivariate analysis showed that the most important predictor was Current Health Expenditure per capita (p = 0.01). Conclusion. The use of medications already considered by many to be obsolete and even dan-gerous due to their low benefi ts/harm ratio seems related to the underdevelopment of a country. There is a need for further research into ways to help these countries make better choices about the use of potentially harmful drugs and other health technologies.