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June 28, 2024Molecular Pharmaceutics

Head-to-Head Comparison of Caco-2 Transwell and Gut-on-a-Chip Models for Assessing Oral Peptide Formulations

John P. Gleeson Stephanie Y. Zhang Natalia Subelzú Jing Ling Becky Nissley Whitney S. Y. Ong Rebecca Nofsinger Filippos Kesisoglou

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Abstract

Oral delivery of potent peptide drugs provides key formulation challenges in the pharmaceutical industry: stability, solubility, and permeability. Intestinal permeation enhancers (PEs) can overcome the low oral bioavailability by improving the drug permeability. Conventional

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Cite This Study

Gleeson et al. (2024) studied this question.

synapsesocial.com/papers/68e62ad5b6db6435875bdd9f https://doi.org/10.1021/acs.molpharmaceut.4c00210

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