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June 28, 2024New BiotechnologyOpen Access

Ectoine enhances recombinant antibody production in Chinese hamster ovary cells by promoting cell cycle arrest

Salinthip Jarusintanakorn Enrico Mastrobattista Montarop Yamabhai

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Abstract

Chinese hamster ovary (CHO) cells represent the most preferential host cell system for therapeutic monoclonal antibody (mAb) production. Enhancing mAb production in CHO cells can be achieved by adding chemical compounds that regulate the cell cycle and cell survival pathways. This study investigated the impact of ectoine supplementation on mAb production in CHO cells. The results showed that adding ectoine at a concentration of 100 mM on the 3

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Cite This Study

Jarusintanakorn et al. (2024) studied this question.

synapsesocial.com/papers/68e62c1bb6db6435875be6b6 https://doi.org/10.1016/j.nbt.2024.06.006

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