Review reveals that clinical trials fail to capture real-world drug outcomes in diverse populations, highlighting the essential bridging role of pharmacoepidemiology.
Pharmacoepidemiology (PE) is a hybrid of epidemiology and pharmacy that studies the patterns and associated benefits and risks of medicines used in a given population. This discipline evolved from the lack of clinically relevant information derived from small and unrepresentative human samples in clinical trials (usually randomized control trials), meaning that once a medicine reaches the market for use in a more diverse population, little is known about the efficacy and safety in the “real‐world.”
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Jodie Hillen (2024) studied this question.
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