Meta-analysis of CTLA-4 Gene A/G +49 Polymorphism and Susceptibility to Graves' Disease

Cytotoxic T - Lymphocyte Antigen-4 (CTLA-4) gene located on 2q33 in human which plays an important role in the down regulation of CD28 interaction with the ligands on the surface of antigen-presenting cells (APCs). CTLA4 molecule is a susceptible gene for the severity of Graves’ disease (GD). Recent research studies showed that the association between the CTLA4 exon-1 49A/G single nucleotide polymorphism (SNP) and the developing Graves’ disease. So, the present study is planned to perform the meta-analysis to explore the association between the SNP49 and GD susceptibility in human beings to the society. SNP public databases and SNP databases showed that the genetic association of diseases such as obesity, diabetes, osteoporosis, asthma, hypertension, renal failure, heart diseases and thyroidism etc.