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This review article explores innovative methods and recent advancements in the reclamation of organic solvents from reaction media, underscoring the principles of green chemistry and the goal of achieving a zero-waste synthesis chain. Effective solvent recovery and waste management are critical for sustainable industrial practices. Acetonitrile, in particular, is a vital solvent in the pharmaceutical and fine chemical industries due to its high polarity and stability. Efficient recovery of acetonitrile is essential to mitigate environmental impacts and reduce costs. This review examines various techniques dedicated to acetonitrile recovery, including pressure-swing, batch, and heterogeneous distillation, as well as advanced separation technologies like ionic liquids and phase equilibrium studies. A comparison of these techniques is presented, highlighting their effectiveness and optimization in solvent recovery. Environmental impacts and sustainability are addressed through comprehensive life cycle assessments and green chemistry practices, providing insights into current trends and innovations in solvent recovery for enhanced sustainability and economic efficiency.
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Vardan Sargsyan (2024) studied this question.
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