Synthesis, Spectroscopic and Biological Activity Studies of Zinc(II) Complexes of N1,N’4-bis((1E,2E)-2-(hydroxyimino) -1-(4-R)-phenylethylidene) terephthalohydrazide Schiff Base

In this work, we have synthesized various zinc metal complexes with different acylhydrazoneoxime derivatives. The synthesis process involved condensation of para-substituted isonitrosoacetophenones (4-R-INAP) and terephthalohydrazide (TPHD). To produce these complexes, we reacted zinc chloride with various 4-substituted isonitrosoacetophenone terephthalohydrazide ligands (4-R-INAP-TPHD), where R= -H, -CH3, -OCH3 and -Cl. We employed different physicochemical and spectroscopic methods like elemental analysis, TG-DTA, UV-visible, FTIR, and NMR spectroscopy, electrical conductance, and magnetic susceptibility to analyze the Schiffs base and zinc metal complexes. In addition, we tested the antibacterial activities of these compounds against selected bacteria strains.