Bone Incorporation of a Poly (L-Lactide-Co-D, L-Lactide) Internal Fixation Device in a Rat’s Tibia: Microtomographic, Confocal LASER, and Histomorphometric Analysis

Harrisson Lucho Mamani-Valeriano; Nelson Padilha Silva; Heloisa Helena Nímia; Maísa Pereira‐Silva; Maria Eduarda de Freitas Santana Oliveira; Letícia Gabriella de Souza Rodrigues; Paulo Matheus Honda Tavares; Henrique Hadad; Laís Kawamata de Jesus; Ana Flávia Piquera Santos; Débora Barros Barbosa; Pier Paolo Poli; Carlo Maiorana; Paulo Sérgio Perri de Carvalho; Roberta Okamoto; Francisley Ávila Souza

doi:10.3390/biology13070471

June 26, 2024BiologyOpen Access

Bone Incorporation of a Poly (L-Lactide-Co-D, L-Lactide) Internal Fixation Device in a Rat’s Tibia: Microtomographic, Confocal LASER, and Histomorphometric Analysis

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Key Points

Biodegradable PLDLLA fixation devices demonstrated progressive bone interface contact and new bone formation across cortical and cancellous tibia sites.
Randomized animal trial evaluated 32 male Wistar rats across 7, 14, 28, and 42 days using histomorphometric analysis and microtomography.
These findings indicate favorable mineral apposition rate and biocompatibility for internal fixation, though rat model constraints require clinical validation.

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Implication

Randomized preclinical study reveals bone incorporation of PLDLLA fixation devices in rat tibiae, suggesting viability for internal skeletal fixation.

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Mamani-Valeriano et al. (2024) studied this question.

synapsesocial.com/papers/68e633b3b6db6435875c5890 https://doi.org/10.3390/biology13070471

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Bone Incorporation of a Poly (L-Lactide-Co-D, L-Lactide) Internal Fixation Device in a Rat’s Tibia: Microtomographic, Confocal LASER, and Histomorphometric Analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Bone Incorporation of a Poly (L-Lactide-Co-D, L-Lactide) Internal Fixation Device in a Rat’s Tibia: Microtomographic, Confocal LASER, and Histomorphometric Analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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