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June 26, 2024Open Access

Supplementary Figure 2 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response

Yu Amanda Guo Tanmay Kulshrestha Mei Mei Chang Irfahan Kassam Egor Revkov Simone Rizzetto Aaron C. Tan Daniel S.W. Tan Iain Beehuat Tan Anders J. Skanderup

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Key Points

Transcriptome deconvolution reveals an absence of cancer cell expression signature during immune checkpoint blockade response, confirming distinct cell contributions.
Validation of bulk tumor expression deconvolution across ICB-treated cohorts confirms computational consistency, and it accurately separates diverse cell populations.
Highlights the necessity of transcriptome deconvolution in tumor profiling, and external validation across larger clinical cohorts remains warranted for therapeutic insight.

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Implication

Validation analysis demonstrates bulk tumor transcriptome deconvolution performance in ICB-treated cohorts, highlighting cell expression dynamics.

Abstract

Validation of bulk tumor expression deconvolution in ICB-treated cohorts.

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Cite This Study

Guo et al. (2024) studied this question.

synapsesocial.com/papers/68e633b3b6db6435875c5912 https://doi.org/10.1158/2767-9764.26106973

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 2 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response2024
2Supplementary Figure 1 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response2024
3Supplementary Figure 1 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response2024
4Supplementary Figure 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response2024
5Supplementary Figure 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response2024

Supplementary Figure 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response2024
Supplementary Figure 4 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response2024
Supplementary Figure 4 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response2024