Comprehensive Assessment of the Effect of Single Nucleotide Polymorphism of the CLOCK Gene rs1801260 on the Development of Metabolic Disorders in Obese Individuals
Observational study reveals increased metabolic risk from the CLOCK rs1801260 TC genotype in obese individuals, highlighting the circadian clock's role in metabolic health.
Key Points
Elevated body mass index and waist circumference correlate with the heterozygous CLOCK gene rs1801260 TC genotype during chronic desynchronosis.
A higher body mass index of 32.5 kg/m2 occurred in TC carriers, exceeding TT homozygote values by 4% alongside an increased waist circumference.
Assessment of glycemic profile indicators in 150 individuals highlights an increased risk of developing metabolically unhealthy obesity with sleep loss.