Insects are considered as a potentially eco-friendly, highly nutritious, and protein-rich food source. We evaluated the effects of Tenebrio molitor (Tm) and Protaetia brevitarsis seulensis (Pbs) extracts in a mouse model of D-galactose (D-Gal) aging, focusing on the impact of the insect extracts on neuronal viability, blood–brain barrier (BBB) integrity, and gut health. D-gal administration led to cognitive and behavioral deficits and increased anxiety levels. Tm and Pbs extracts increased glutathione, superoxide dismutase, and catalase levels; protected neurons in the brain, preventing BBB disruption and brain edema; and prevented the deposition of amyloid-β plaques in the prefrontal cortex and hippocampus. Furthermore, both extracts prevented disruption of gut epithelial integrity and mitigated intestinal inflammation. Our findings suggest a novel therapeutic potential of insect extracts against aging-related changes; they can be used as functional foods in the aging process by controlling the BBB and intestinal health.
No takes yet. Share an insight, caveat, or question.
Trân et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: