A series of pyrimidine-based antifungals with anti-mold activity disrupt ER function in Aspergillus fumigatus

Fungal infections are a major contributor to morbidity and mortality among immunocompromised populations. Moreover, fungal disease caused by molds are difficult to treat and are associated with particularly high mortality. To address the need for new mold-active antifungal drugs, we performed a high-throughput screen with