New Spectrophotometric Method for the Estimation of Fenofibrate

Fenofibrate is a Antihyperlipidemic used to treat cholesterol. New spectrophotometric technique have been developed for the estimation of Fenofibrate in pharmaceutical dosage form. Double beam UV-VIS spectrophotometer (SHIMADZU Model UV-1800) was used for the present study. Fenofibrate has shown linearity over the concentration range 0.5-40 µg/mL for acetate buffer (pH 4.0), phosphate buffer (pH 7.8), 0.1M sodium hydroxide and 1-40 µg/mL for phosphate buffer (pH 5.8), and distilled water respectively and the methods were validated as per ICH guidelines. The proposed methods are simple, economical and can be successfully applied for the assay of Fenofibrate in pharmaceutical dosage forms.