Nutritional Medical Therapy on Inflammatory Markers of Critically Ill Patients in Intensive Care Unit; Study on Crp and Procalcitonin

Abstract Background and objectives: Malnutrition is the most frequent complication in critically ill patients which can be characterized by an increase in inflammatory markers, namely CRP and Procalcitonin, which adversely affects patient outcomes. Nutritional therapy plays an important role in the management of critically ill patients. This study aims to determine the relationship of nutritional medical therapy with CRP and Procalcitonin in critically ill patients. Methods: This study used a retrospective cohort study design on critical patients at Wahidin Sudirohusodo Teaching Hospital in 2020-2021 as many as 250 subjects who met the inclusion criteria by screening for malnutrition using the m-Nutric score, laboratory examination of CRP and Procalcitonin and getting nutritional medical therapy. Results: In the variable energy <600 and mNutric low risk of CRP I and II: 127.70±79.01 vs 161.15±131.45 (p=0.655) while Procalcitonin I and II: 27.79±50.51 vs 11.97±17.21 (p=0.054). In the variable energy ≥ 600 kcal mNutric score low risk for CRP I and II: 154.91±108.66 vs 95.74±74 (p=0.009) while Procalcitonin I and II 15.54±39.49 vs 37.64±62.62 (p=0.841). In the variable energy ˂ 600 kcal and mNutric score high risk of CRP I and II 148.50±47.98 vs no value (p = no) while Procalcitonin I and II: 73.01±73.66 vs 20.42±35.19 (p=0.138). In the variable energy ≥ 600 kcal and mNutric score high risk of CRP I and II 120.95±41.64 vs 76.13±21.16 (p=0.109) while Procalcitonin I and II: 58.20±71.87 vs 35.55±50.90 (p=0.011). In the variable of energy ≥ 600 kcal and mNutric score low risk found a statistically significant decrease in CRP levels and mNutric score high risk found a statistically significant decrease in Procalcitonin levels. Conclusion: There is a relationship between Nutritional Medical Therapy on CRP and Procalcitonin in critically ill patients in the Intensive Care Unit with statistically significant results.