The rRNA epitranscriptome and myonuclear SNORD landscape in skeletal muscle fibers contributes to ribosome heterogeneity and is altered by hypertrophic stimulus

Ribosomal RNAs (rRNAs) are posttranscriptionally modified by 2′ O-methyl (2′- O-Me). This study applied RiboMeth-seq (RMS) to detect changes in 2′- O-Me levels during skeletal muscle hypertrophy, uncovering transient diversification of the ribosome pool in skeletal muscle fibers. This work implies a role for ribosome heterogeneity in skeletal muscle growth and adaptation.