Answers are grounded in this paper and cite their sources.
Preclinical study reveals proteome-wide metabolic shifts following trehalose administration in high-fat-fed mice, highlighting molecular mechanisms against liver steatosis.
Metabolic dysfunction-associated fatty liver disease has been well documented as a key independent risk factor for the development of atherosclerosis. A growing body of evidence suggests that due to its numerous favorable molecular effects, trehalose may exert beneficial effects in counteracting liver steatosis. In our previous study, we described the antiatherosclerotic and antisteatotic properties of trehalose, which we attributed to the induction of autophagy. Considering the pleiotropic activities of trehalose, our present study aimed to extend our preliminary results with the comprehensive examination of proteome-wide changes in the livers of high-fat-fed apoE-/- mice.
No takes yet. Share an insight, caveat, or question.
Pogoda et al. (2024) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: