Safety and Efficacy of Sodium-Glucose Transport Protein 2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Kidney Transplant Recipients: Synthesis of Evidence v1

A systematic review and meta-analysis will be conducted aiming to investigate the efficacy and safety of Sodium-Glucose Transport Protein 2 inhibitor (SGLT2-i) and Glucagon-like Peptide-1 Receptor Agonist (GLP1-RA) treatment in kidney transplant recipients, with and without diabetes mellitus. A systematic literature search will be performed and the quality of the included studies will be critically assessed using validated tools. Statistical meta-analysis will be performed using random-effects models and exploring potential sources of heterogeneity. The certainty of the existing evidence will be critically evaluated following the GRADE approach.