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June 21, 2024Biomedicine & PharmacotherapyOpen Access

Dual therapy with phospholipase and metalloproteinase inhibitors from Sinonatrix annularis alleviated acute kidney and liver injury caused by multiple snake venoms

Kepu Fu Jianqi Zhao Lipeng Zhong Haiyan Xu Xinhui Yu Xiaowen Bi Chunhong Huang

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Abstract

Snakebite envenomation often induces acute kidney injury (AKI) and acute liver injury (ALI), leading to augmented injuries and poor rehabilitation. Phospholipase A

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Fu et al. (2024) studied this question.

synapsesocial.com/papers/68e63c18b6db6435875ce0ef https://doi.org/10.1016/j.biopha.2024.116967

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for EnvenomationOriginal Research · 2016 · 225 citations
2Naja atra SVPLA2 Aggravates Acute Kidney Injury Through Metabolic Reprogramming-Dependent Macrophage Polarization and Defective EfferocytosisOriginal Research · 2026 · 3 citations
3Local Tissue Damage Induced by Snakebite Envenoming: Mechanisms and Therapeutic AdvancesReview · 2026
4Look what you make my tissues do: The role of metalloproteinases and their inhibitors in Bothrops snakebitesOriginal Research · 2026 · 1 citations
5Targeting Key Enzymatic Snake Venom Proteins Using Repurposed Small Molecule Inhibitors: Emerging Adjuncts to Antivenom TherapyClinical Trial · 2026 · 4 citations

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