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June 21, 2024Open Access

RUNX1 Isoforms Regulate RUNX1 and Target-Genes Differentially in Platelets-Megakaryocytes: Association with Clinical Cardiovascular Events

Liying Guan Deepak Voora Rachel A. Myers Fabiola Del Carpio‐Cano A. Koneti Rao

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Abstract

Hematopoietic transcription factor RUNX1 is expressed from proximal P2 and distal P1 promoter to yield isoforms RUNX1 B and C, respectively. The roles of these isoforms in RUNX1 autoregulation and downstream-gene regulation in megakaryocytes and platelets are unknown.

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Cite This Study

Guan et al. (2024) studied this question.

synapsesocial.com/papers/68e63d21b6db6435875cf431 https://doi.org/10.1101/2024.06.18.599563

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