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June 20, 2024Journal of EthnopharmacologyOpen Access

Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway

Yao Zhang Fei Ge Yamin Luo Xuenian Ji Zijian Liu Yuehua Qiu Jianchen Hou Ranran Zhou Zhao Cai-hong Xu Qianwei Shujing Zhang Xue Yu Chunguo Wang Dongyu Ge Fengxian Meng Xiaohua Tao

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Abstract

Paeonol (PAE) and glycyrrhizic acid (GLY) are predominate components of 14 blood-entering ones of Piantongtang No. 1, which is a traditional Chinese medicine prescription for chronic migraine with minimal side effects. Both paeonol and glycyrrhizic acid exhibit analgesic, neuroprotective and anti-inflammatory properties individually. Our previous research has highlighted their combined effect (PAE + GLY) in ameliorating migraine symptoms. However, there are not yet any studies exploring the mechanism of action of PAE + GLY in the treatment of migraine.

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Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e63e32b6db6435875d0418 https://doi.org/10.1016/j.jep.2024.118464

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Rosmarinic acid attenuates photophobia, hyperalgesia and neuroinflammation during nitroglycerine induced migraine like headache in miceOriginal Research · 2025 · 1 citations
2Pharmacological Modulation of the Kynurenine Pathway Using PF-04859989 Modulates PACAP Signaling in Migraine-Relevant Trigeminal SensitizationOriginal Research · 2026
3Mechanistic Insights into Toutongping Granule for Migraine: A Multi-Pathway Intervention Study in RatsOriginal Research · 2026 · 1 citations
4Phenylephrine per se or Combined with Pregabalin Ameliorates Mononeuropathic Pain in RatsOriginal Research · 2026 · 1 citations
5Rutaecarpine alleviates migraine in nitroglycerin-induced mice by regulating PTEN/PGK1 signaling pathway to activate NRF2 antioxidant systemOriginal Research · 2023 · 22 citations

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