We present the SERS-based detection of biomolecules in complex biological matrices. This includes the detection of co-factors in bacterial membranes, drugs and its metabolites in clinically relevant matrices as well as cancer-relevant marker in saliva. To overcome the complexity of the biological matrix, a high affinity of the target analyte is essential, which is improved by sample preparation processes or specific enrichment on the sensor surface.
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Cialla‐May et al. (2024) studied this question.
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