Abstract Twelve new compounds (Piperazine side chains modified 4-Aminoquinoline Mannich Bases) were synthesized and characterized utilizing a variety of analytical and spectroscopic techniques. All the synthesized compounds were screened for in vitro antimalarial activity aganist 3D7 strain of Plasmodium falciparum. In vitro antimalarial screening revealed that the all synthesized compounds exhibited minimum inhibitory concentrations (MIC) ranging from 3.9 to 31.25 μg/ml. One compound 9l (MIC=3.9 μg/ml or1.953±0.10μM) was found most potent against chloroquine sensitive 3D7 strain of Plasmodium falciparum which is comparable to standard drug chloroquine (MIC=0.4 μg/ml or 0.106±0.01 μM).
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Singh et al. (2024) studied this question.
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