The effect of Beta-aminobutyric acid (BABA) on Staphylococcus aureus bacteria and some interleukins

β-amino butyric acid (BABA) is one of the rare free compounds found in nature. It is recognized for its ability to enhance plant immunity against a wide range of diseases, including viruses, bacteria, fungus, and worms. This research aimed the effects of BABA on Staphylococcus aureus isolated from Sprague-Dawley male rats' feces and on IL-4, IL-10, and IL-27. The study included 25 Sprague-Dawley male rats, divided into five groups, each group contain 5 rats, The first group for control, while the second, third ,fourth, and fifth groups for rats dosed orally with different concentration of BABA as (0.250 ,0.315,0.358,0.360) mg/kg respectively, all rats dosed twice in week and for four weeks. The result show one isolate from the control group was found at each stages (T1, T2, T3, T6, T7) and none at (T5 and T8). In the second group, one isolate was in each stage T2, T3, T7, and none in T1, T5, and T8. In the third group, one isolate was at each stage (T2, T3, T4, and T7) and none in other stages. Groups four and five showed no Staphylococcus aureus growth. The study show significant increase of IL-27 in fifth group (98.60 ±1.57) in comparison with control (70.60 ±0.75). Furthermore significant increase IL-10 in fourth and fifth groups (1082.83 ±23.33, 1104.36 ±43.44) respectively in comparison with control (504.06 ±7.12). While IL-4 decrease in the fourth and fifth groups (8.04 ±0.78 , 14.07 ±0.16) respectively in comparison with control (34.89 ±1.51).