Rücktitelbild: A Fluorinated Chaperone Gives X‐ray Crystal Structures of Acyclic Natural Product Derivatives up to 338 Molecular Weight (Angew. Chem. 27/2024)

Like a hand in glove, a glove that fits many different sizes, is how TFM, a new crystallization chaperone for liquid molecules, packs when it crystallizes as a solvate, leading to X-ray diffraction-based crystal structures that cannot be obtained otherwise. This and a new temperature jump crystallization protocol is presented in the Research Article (e202402976) by Clemens Richert and colleagues. The cover graphic shows the analytes and the chaperone, together with the crystal lattice of the squalene solvate.