Evaluation of anti-arthritic activity of Hyptis suaveolens seeds in rats

Rheumatoid arthritis has been treated with Hyptis suaveolens (L) poit. seeds. There has been no pharmaceutical assessment for rheumatoid arthritis. A study aims to assess the anti-arthritic properties of aqueous extract of Hyptis suaveolens (L) poit… seeds (AEHS). Standard techniques were used for phytochemical analysis. Tested anti-arthritic potential in-vitro (25-800µg/ml egg albumin) and in vivo (200 and 400 mg/kg egg albumin induced arthritic model). Chemicals such alkaloids, sugars, flavonoids, phenols, and terpenoids were found. Results showed 75% reduction of protein denaturation at 800µg/ml in-vitro. According to the Egg albumin model, AEHS considerably (P < 0.0001) inhibits changes in paw volume, joint diameter, and body weight. It also improves hematological, biochemical, and histopathological levels. The findings confirm the traditional usage of Hyptis suaveolens(L)poit. seeds to treat rheumatoid arthritis.