Calcium pyrophosphate dihydrate (CPPD) crystal deposition may cause acute arthritis (pseudogout), cartilage degeneration identified radiographically as chondrocalcinosis (CC), and other chronic degenerative joint changes in patients aged > 60 years. The few reported cases of CPPD disease in younger patients have been associated with underlying genetic or metabolic conditions. 1,2
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Bolivar-Wagers et al. (2024) studied this question.
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