A Study to Correlate Evoked Gamma Oscillations With Clinical and Demographic Variables in First Degree Relatives of Patients of Schizophrenia With at-Risk Mental State.

Background:EEG has shown that schizophrenia is characterized by alterations in synchrony and oscillatory activity in a variety of paradigms,particularly in the gamma range.A study was conducted to correlate evoked gamma oscillations with clinical and demographic variables in first-degree relatives of patients of schizophrenia with At-risk mental states (ARMS) and healthy controls (HC).Methods:This was a Hospital-based,cross-sectional study conducted between 2017 to 2019. Right-handed, normal-hearing individuals of both genders, aged > 18 years, FDRs of patients meeting diagnostic criteria for schizophrenia, and age and sex-matched healthy controls were included in the study. All participants underwent EEG recording in a light-attenuated and sound-proof room with a supine position. P<0.05 was considered to be statistically significant.Results:The finding suggests no significant difference between the two groups regarding religion, education, occupation, socioeconomic status, family income, and habitat. The continuous variable (age) was compared using the T-test. Correlations of low gamma (30-45 Hz) spectral power between age and regions were statistically not significant among ARMS & HC. Conclusions: The finding suggests no significant difference between the two groups regarding religion,education,occupation,socioeconomic status,family income,and habitat.