Succinyl Curcumin Conjugated Chitosan Polymer-Prodrug Nanomicelles: A Potential Treatment for Type-II Diabetes in Diabetic Balb/C Mice

Diabetes mellitus is a chronic metabolic disorder marked by elevated blood sugar levels, leading to organ dysfunction. Curcumin, derived from turmeric, exhibits promise in managing type II diabetes. Amphipathic polymer prodrugs were synthesized by conjugating curcumin with chitosan through succinic anhydride. Nanomicelles, formed via dialysis of amphipathic polymer prodrug, were spherical with an average hydrodynamic size of 57 nm. In vitro release studies revealed 97% curcumin release at pH 5 in 7 days. A 21-day experiment on diabetic mice compared nano micelles, standard drugs, and free curcumin’s impact on fasting blood glucose. The study showcased gradual, controlled curcumin release from nano micelles, suggesting their potential in type II diabetes treatment.