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June 12, 2024HematologyOpen Access

Detection of α-thalassemia South-East Asian deletion based on a fully integrated digital polymerase chain reaction system DropXpert S6

Youqiong Li Junwei Ye Liang Liang Xiao Tan Lihong Zheng Ting Qin Linfen Yu

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Abstract

This study aimed to establish a droplet digital polymerase chain reaction (ddPCR) assay for South-East Asian (SEA) deletion based on a fully integrated digital PCR system DropXpert S6.

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Cite This Study

Li et al. (2024) studied this question.

synapsesocial.com/papers/68e650a7b6db6435875e0dd3 https://doi.org/10.1080/16078454.2024.2365596

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Nanoplate Digital PCR for Identification of α0-Thalassemia (SEA Deletion): Carrier Screening and Possible Application to Prenatal DiagnosisOriginal Research · 2026
2Development of loop-mediated isothermal amplification (LAMP) combined with a lateral flow dipstick DNA biosensor for detection of α thalassemia 1 [Southeast Asia (SEA), --SEA deletion]Original Research · 2026
3Enhancing Hemoglobin Bart’s hydrops fetalis syndrome prevention: a single-tube multiplex real-time PCR assay for the comprehensive detection of four significant α <sup>0</sup> -thalassemia deletions (-- <sup>SEA</sup> , -- <sup>THAI</sup> , -- <sup>CR</sup> , and -- <sup>SA</sup> ) found in ThailandDiagnostic Study · 2026
4Simultaneous --SEA, β-thalassaemia and haemoglobinopathy detection through the development of α-thalassaemia early eluting peakOriginal Research · 2026
5Retrospective study and implementation of a low-cost LAMP-turbidimetric assay for screening α<sup>0</sup>-thalassemia (SEA deletion): preventing and controlling Hb Bart’s hydrops fetalis syndrome in Thailand2024 · 4 citations

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Detection of common deletional α‐thalassemia‐2 determinants by PCR1994
Lateral flow-based assay for simple and rapid visual detection of Asian-type DEL2026
Diagnostic performance of nanopore sequencing technology for detecting thalassemia and hemoglobinopathy2026

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