Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report

Methotrexate (MTX)‑related lymphoproliferative disease (LPD) is one of the most prominent late complications associated with MTX treatment. Although MTX‑related LPD exhibits a relatively high incidence of extranodal disease, the incidence of disease in a urinary bladder is very low. The present study reports the case of a patient with MTX‑related LPD involving a urinary bladder mass. A 75‑year‑old female patient, who had been receiving MTX for ~15 years, was referred to the hospital due to fever and hematuria. A computed tomography scan revealed the thickening of the urinary bladder wall, hydronephrosis and lymph node swelling. The histopathological findings of the urinary bladder mass resulted in a diagnosis of MTX‑related LPD. Although MTX withdrawal did not have any effect, the subsequent chemotherapy resulted in complete remission. Although MTX‑related LPD in the bladder is rare, it is pertinent to consider MTX‑related LPD when hematuria is observed during MTX therapy.