Recent Advances in Gastrointestinal Neuroendocrine Tumor Classification

Gastrointestinal Neuroendocrine Tumors (GI-NETs) encompass a broad spectrum of neoplasms arising from neuroendocrine cells, showcasing diverse clinical manifestations and behaviors. The evolution of GI-NET classification has been marked by advancements in histopathology, molecular biology, imaging, and biomarker discovery. Traditional classifications relied on histological features, while modern approaches integrate molecular profiling and imaging modalities to refine tumor characterization and guide personalized treatment strategies. This mini-review provides an overview of the historical progression and current landscape of GI-NET classification systems, highlighting recent breakthroughs in molecular characterization and the integration of imaging and biomarkers.