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June 11, 2024Open Access

Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer

Mikayla B. Bowen Brenda Melendez Qian Zhang Diana Moreno Leah Peralta Wai Kin Chan Collene Jeter Lin Tan Malgorzata Anna Zal Philip L. Lorenzi Kenneth Dunner Richard K. Yang Russell R. Broaddus Joseph Celestino Nisha Gokul Elizabeth M. Whitley Rosemarie Schmandt Karen H. Lu Hyun-Eui Kim Melinda S. Yates

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Abstract

Lynch syndrome (LS) is defined by inherited mutations in DNA mismatch repair genes, including

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Bowen et al. (2024) studied this question.

synapsesocial.com/papers/68e65550b6db6435875e47d2 https://doi.org/10.1101/2024.06.10.596841

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Abstract IA013: Unique metabolic changes in Lynch syndrome-associated endometrial cancer2024
2Abstract A010: Mitochondrial depletion and metabolic reprogramming is a novel phenotype of Lynch syndrome-related endometrial carcinogenesis2024
3Germline MLH1 and MSH6 mutations from two Lynch syndrome families identified in a patient with early-onset of endometrial cancer: A case report2024 · 1 citations
4Lynch Syndrome-associated Genomic Variants2024 · 3 citations
5Expanding the molecular spectrum of Lynch syndrome: endometrial carcinoma with combined MSH2–EPCAM deletionOriginal Research · 2026