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June 10, 2024Frontiers in Cellular and Infection MicrobiologyOpen Access

Broad synergistic antiviral efficacy between a novel elite controller-derived dipeptide and antiretrovirals against drug-resistant HIV-1

Federica Giammarino Anders Sönnerborg Rafael Ceña Diez

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Abstract

The naturally occurring dipeptide Tryptophylglycine (WG) is enhanced in human immunodeficiency virus (HIV-1) infected Elite Controllers (EC). We have shown that this dipeptide has an anti-HIV-1 effect and evaluated now its synergistic antiretroviral activity, in combination with current antiretrovirals against multi-drug resistant HIV-1 isolates.

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Giammarino et al. (2024) studied this question.

synapsesocial.com/papers/68e6577ab6db6435875e6a14 https://doi.org/10.3389/fcimb.2024.1334126

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