Preclinical investigation demonstrates improved immune responses to Pseudomonas aeruginosa in trained macrophages, highlighting therapeutic potential against cystic fibrosis damage.
OBJECTIVE P. AERUGINOSA: (PA), the major pathogen of lung cystic fibrosis (CF), polarizes macrophages into hyperinflammatory tissue damaging phenotype. The main aim of this study was to verify whether training of macrophages with β-glucan might improve their response to P. aeruginosa infections.
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Ciszek‐Lenda et al. (2024) studied this question.
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