Efficacy and Safety of CONAN® Proctological Cream Formulation in the Topical Treatment of Haemorrhoidal Disease and Anal Fissures: A Randomized Controlled Clinical Trial

Background: To evaluate the role of CONAN® Proctological Cream containing escin, hesperidin and hyaluronic acid in topical treatment of haemorrhoidal disease and anal fissures and its potential efficacy in reducing related symptoms. Methods: Forty patients with haemorrhoidal disease and anal fissures were enrolled. Of them, 20 were randomized to receive the medical device CONAN® Cream (Group A) and 20 to the untreated control group (Group B). At each scheduled visit, total symptoms were assessed and recorded by assigning a Numerical Rating Scale score from 0 to 10. The adverse events reported by study subjects were also assessed and recorded. Results: At the end of observational period the group treated with CONAN® Proctological Cream obtained a statistically significant improvement (p<0.001) in total symptoms calculated using the NRS score compared to the untreated group. No adverse effects were reported. Conclusions: CONAN® Proctological Cream is safe and efficacious in the treatment of symptoms associated with haemorrhoidal disease and anal fissures.