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June 6, 2024HaematologicaOpen Access

Epstein-Barr Virus and immune status imprint the immunogenomics of non-Hodgkin lymphomas occurring in immune-suppressed environments

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Authors

MBMarine BaronKLKarim LabrècheMVMarianne Veyri

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Overview

Immunogenomic analysis reveals altered neoepitope loads in immunodeficient lymphoma patients, highlighting opportunities for targeted T-cell therapies.

Key Points

  • Tumor mutational burden and neoepitope counts decrease significantly in Epstein-Barr virus-positive non-Hodgkin lymphomas, regardless of patient immune status.
  • Tumor mutational burden averaged 2.2 mutations per megabase in viral cases compared to 3.4 in negative cases, accompanied by reduced neoepitopes.
  • Tumor whole-exome and RNA sequencing reveals altered tumor microenvironment features, while preserved neoepitopes support future T-cell immunotherapies.

Cite This Study

Baron et al. (2024) studied this question.

synapsesocial.com/papers/68e65d10b6db6435875eb3f9https://doi.org/10.3324/haematol.2023.284332
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