A Comparative Analysis of Side Effects from the Third Dose of COVID-19 Vaccines in Palestine and Jordan

In this cross-sectional study, the prevalence and characteristics of adverse effects following the administration of the third dose of the coronavirus disease 2019 (COVID-19) vaccines were compared between recipients in Palestine and Jordan. Data were collected via an online survey targeting random samples from both countries. In Palestine, the primary factors predisposing individuals to side effects after the third dose were prior adverse reactions to earlier vaccinations and a history of COVID-19 infection before vaccination. Minor contributing factors included food sensitivities, weight, and drug sensitivities. In Jordan, gender, smoking, and food sensitivities emerged as the most significant variables influencing the development of side effects, with age being a secondary factor. Weight, COVID-19 infection post-vaccination, and prior adverse reactions to earlier doses were less significant. In Palestine, individuals with diabetes and respiratory diseases were more prone to adverse effects, followed by those who are obese, and those with cardiovascular diseases, osteoporosis, thyroid disorders, immune diseases, cancer, arthritis, and hypertension. In Jordan, participants with arthritis were the most likely to develop side effects, followed by those who are obese, and those with respiratory conditions and thyroid disorders. These findings confirm that COVID-19 vaccines authorized for use are generally safe, and vaccination remains a crucial tool in curbing the spread of the virus. Acceptance of the third dose has been notable in both Palestine and Jordan, underscoring the value of booster doses in enhancing immunity.