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June 5, 2024Angewandte Chemie International EditionOpen Access

Coupling of Aryl Chlorides with Lithium Nucleophiles Enabled by Molecularly Defined Alkynyllithium Palladium Catalysts

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Authors

JGJonas F. GoebelRuhr University BochumJSJohanna StemmerRuhr University BochumNKNele KrügerRuhr University Bochum

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Overview

Experimental study reveals cross-coupling of aryl chlorides with lithium nucleophiles using alkynyllithium palladium complexes, highlighting a phosphine-free catalytic approach.

Key Points

  • Alkynyllithium palladium catalysts enable efficient cross-coupling of aryl chlorides with diverse lithium nucleophiles without requiring traditional phosphine or carbene ligands.
  • Synthesis of 49 distinct molecules demonstrates broad utility across aryl chlorides and related electrophiles, whereas uncomplexed palladium salts exhibited zero catalytic conversion.
  • Characterization identified a dilithium tetraalkinyl palladate complex as the active species, highlighting practical access to functionalized alkynyl arenes and related target compounds.

Cite This Study

Goebel et al. (2024) studied this question.

synapsesocial.com/papers/68e65f99b6db6435875edbe8https://doi.org/10.1002/anie.202408974
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