June 5, 2024The Veterinary JournalOpen Access

Fibronectin type III domain-containing protein 5 (FNDC5)-like immunoreactivity and mRNA abundance in domestic animal tissues

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Authors

ELE. LaiUniversity of Saskatchewan JSJohn F. SandsUniversity of Saskatchewan SUSuraj UnniappanUniversity of Saskatchewan

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Implication

Laboratory analysis demonstrates FNDC5 precursor expression but undetectable processed irisin in domestic animals, highlighting the need for validated species-specific detection tools.

Key Points

The irisin precursor FNDC5 is present across duck, pig, and horse skeletal muscle tissues, whereas processed irisin remains undetectable in these domestic species.
Serum irisin-like immunoreactivity averaged 13.7 ng/mL in ducks and 15.4 ng/mL in horses, demonstrating circulating precursor detection across domestic farm animals.
Assessment using RT-PCR and multispecies ELISA confirmed FNDC5 precursor expression in pig and duck tissues, but reliable tools are still required to detect processed irisin.

Cite This Study

Lai et al. (2024) studied this question.

synapsesocial.com/papers/68e65faeb6db6435875ee531 https://doi.org/10.1016/j.tvjl.2024.106161

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Implication

Laboratory analysis demonstrates FNDC5 precursor expression but undetectable processed irisin in domestic animals, highlighting the need for validated species-specific detection tools.

Fibronectin type III domain-containing protein 5 (FNDC5)-like immunoreactivity and mRNA abundance in domestic animal tissues

Discussion

Member takes

Implication

Key Points

Cite This Study

Fibronectin type III domain-containing protein 5 (FNDC5)-like immunoreactivity and mRNA abundance in domestic animal tissues

Discussion

Member takes

Implication

Key Points

Cite This Study

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